This guidebook is written primarily for women human rights defenders. It outlines a conceptual framework for women’s human rights activism, pointing to the intersection of multiple factors (age, disability, race, ethnicity, caste, class, national origin, sexual orientation) that can contribute to women’s oppression. The authors argue that those advocating for women’s and gender-based rights are at particular risk for discrimination and violence because they are seen as challenging social norms. They outline strategies for women human rights defenders to advocate for their own rights and safety as they seek to protect the rights of others.