This manual is intended for the training of health workers in countries hardest hit by the AIDS pandemic. The training course is meant to be used to guide health workers through an investigation of the root causes of stigma and discrimination while helping them to understand their own attitudes about HIV, AIDS, and individuals affected by these conditions and how these attitudes might affect the care they offer. The training also provides a review of clients’ rights in receiving health care services, information about the use of standard precautions and proper infection prevention techniques to help minimize the risk of occupational exposure to HIV, and guidance in developing action plans to help the participants put what they have learned into practice at their service settings. The manual consists of a curriculum of 16 individual sessions.